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The Jan Michiels group studies diverse topics related to bacterial survival under stress conditions. Of particular interest are molecular mechanisms involved in antibiotic tolerance or persistence of the opportunistic human pathogen Pseudomonas aeruginosa and the model bacterium Escherichia coli. Additionally, we study the survival of nitrogen-fixing rhizobia upon seed application.

To this end, a combination of molecular genetic, high-throughput genomics and transcriptomics, and microscopic techniques are used. With these results, we aim at contributing to the discovery of novel antibacterials and the improvement of the symbiotic interaction between rhizobia and legumes.

News flash (28 December 2016): Evelien's paper on repurposing an approved anticancer drug as antibacterial got published in Antimicrobial Agents and Chemotherapy, well done! More links on the Publications page.

News flash (13 December 2016): Joran's review on persistence got published in Drug Resistance Updates, congrats to him! Check out the Publications page for more links.

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